Intranasal delivery of metformin using metal-organic framework (MOF)-74-Mg nanocarriers.

Dosage tolerance is one of the translational challenges of using metformin (Met) in brain therapeutics. This paper presents metal-organic framework (MOF)-74-Mg nanocarriers (NCs) for intranasal (IN) delivery of brain-specific agents with a prolonged release time. We confirmed their excellent biocompatibility (5 mg/mL) and intrinsic fluorescence properties (370/500 nm excitation/emission peak) in Neuro-2A cells.

Monkey Lateral Prefrontal Cortex Subregions Differentiate between Perceptual Exposure to Visual Stimuli.

Each day, humans must parse visual stimuli with varying amounts of perceptual experience, ranging from incredibly familiar to entirely new. Even when choosing a novel to buy at a bookstore, one sees covers they have repeatedly experienced intermixed with recently released titles. Visual exposure to stimuli has distinct neural correlates in the lateral prefrontal cortex (LPFC) of nonhuman primates.

The global radiology classroom: increasing accessibility to radiology education.

Aim: Online education provides a wonderful opportunity to democratise global access to quality education. The purpose of the study was to describe and analyse an ongoing online educational initiative of free-to-access radiology webinars.

Materials And Methods: This retrospective review describes our experience in organising an ongoing series of 750-plus free-access educational radiology webinars, including the basic details regarding their timing and frequency, process for topic and speaker selection, webinar promotion, and financial viability.

Binocular Vision Status in Coal Miners.

Context: Low light in mines can cause ocular problems such as binocular vision impairment and poor hand-eye coordination. These eye diseases must be monitored.

Aims: To evaluate the binocular vision status of coal mine workers.