Publications by authors named "A Szostek-Mioduchowska"
Introduction: Prostaglandins (PG) are important regulators of the myometrial contractility in mammals. Endometrosis, a condition characterized by morphological changes in the equine endometrium, also affects endometrial secretory function. However, it remains unclear whether and how endometrosis affects myometrial function.
View Article and Find Full Text PDFThe effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares.
BMC Vet Res
December 2024
Background: Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA) may affect female reproductive function and embryo transport by influencing uterine contractility through its receptors (LPARs).
View Article and Find Full Text PDFA reduction in myometrial contractile activity can lead to inadequate cleaning of the uterine lumen, resulting in persistent endometritis and potentially endometrosis in mares. Oxytocin (OXT) is a key hormonal regulator of myometrial contraction. While epigenetic regulation of myometrial gene expression has been studied in humans, there is limited information on the expression of DNA methyltransferases (DNMTs) and ten-eleven translocation enzymes (TETs) in the myometrium of mares.
View Article and Find Full Text PDFArticle Synopsis
- Increased collagen synthesis in the equine endometrium is linked to endometrosis, with Toll-like receptors (TLRs) playing a key role in inflammation and fibrosis.
- This study examined TLR and collagen gene expression in endometrial tissue from mares at different stages of Kenney and Doig's grading during the follicular phase of the oestrous cycle.
- Results indicated that TLR-2 and TLR-4 expression was higher in certain endometrial categories, suggesting their potential involvement in initiating inflammatory responses, warranting further research into their role as diagnostic markers in equine reproductive health.
The path to fertility in the mare requires an understanding of the hormonal influences, the immune response, genetics, and epigenetic mechanisms involved not only in physiological reproductive processes, but also such pathologies as endometritis and endometrosis. Endometritis may lead to endometrosis establishment. In the presence of endometritis, neutrophils arrive at the mare endometrium, and form neutrophil extracellular traps.
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