Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.

The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.

Targeting Transforming Growth Factor-β Signaling in Primary Open-Angle Glaucoma.

Transforming growth factor-β (TGF-β) may play a role in the pathogenesis of primary open-angle glaucoma (POAG). Elevated levels of TGF-β are found in the aqueous humor and in reactive optic nerve astrocytes in patients with glaucoma. In POAG, aqueous humor outflow resistance at the trabecular meshwork (TM) leads to increased intraocular pressure and retinal ganglion cell death.

[Prospective analysis of outcomes of cataract phacoemulsification with the implantation of the Crystalens accommodative intraocular lens].

Objectives: To evaluate visual outcomes after bilateral implantation of Crystalens accommodative intraocular lenses. Material and methods: The study group consisted of 20 patients (40 eyes) who underwent uneventful phacoemulsification through a 2.8 mm wide clear corneal incision followed by the implantation of an accommodative intraocular lens Crystalens HD or Crystalens AO.

Intraoperative floppy iris syndrome – epidemiology and clinical assessment.

Purpose: To assess the incidence, and to identify medications and clinical features associated with intraoperative floppy iris syndrome in patients undergoing cataract surgery. Material and methods: The non-randomized, observational, prospective study was performed in 616 eyes (610 patients) after cataract surgery to determine the incidence of intraoperative floppy iris syndrome and the medications associated with its higher prevalence. We used a slit lamp adapted optical coherence tomography to evaluate anterior segment of 155 eyes (154 patients), measuring pupil diameter before and after the use of mydriatics and assessing the pre-dilated iris thickness at the dilator and sphincter muscle region.

The effect of the selected factors on corneal endothelial cell loss following phacoemulsification.

Introduction: Corneal endothelium is a single layer of cells, which do not regenerate. Damage to the endothelium can take place in the course of certain diseases and after intraocular operations. When the number of endothelial cells decreases, corneal decompensation can occur.