Publications by authors named "A Symington"

Article Synopsis
  • - The population of Newfoundland and Labrador primarily descends from 18th-19th century settlers from England and Ireland, with genetic studies showing it's an isolated founder population with limited diversity.
  • - A study analyzed 1,110 Y chromosomes and identified 160 distinct haplogroups, predominantly of the R1b type, mirroring the haplogroups found in English and Irish populations.
  • - The research highlighted geographical and religious clustering within the population, indicating that historical settlement patterns and limited immigration have shaped the genetic structure of Newfoundland and Labrador.
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Catalytic activity is affected by surface morphology, and specific surfaces display greater activity than others. A key challenge is to define synthetic strategies to enhance the expression of more active surfaces and to maintain their stability during the lifespan of the catalyst. In this work, we outline an approach, based on density functional theory, to predict surface composition and particle morphology as a function of environmental conditions, and we apply this to CeO nanoparticles in the presence of co-adsorbed HO and CO as an industrially relevant test case.

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The criminalization of HIV non-disclosure represents a significant issue of concern among people living with HIV, those working across the HIV sector, public health practitioners, and health and human rights advocates around the world. Recently, the government of Canada began a review of the criminal law regarding HIV non-disclosure and invited feedback from the public about potential reforms to the Criminal Code. In light of this public consultation, this commentary examines social science research from Canadian scholars that documents the intersecting damaging effects of HIV criminalization.

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Background: Cardiovascular disease affects over 7 million people in the UK and statins are often prescribed to mitigate cardiovascular risks. The effect of statins on a number of cancers is debated and their effect on Bacillus Calmette-Guérin (BCG) responsiveness in non-muscle invasive urinary bladder cancer (NMIBC) is not fully understood.

Aims: This study aims to explore the difference in HMG Co-A reductase (HMGCR) expression in NMIBC on immunochemistry in BCG responders and non-responders while on statins.

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The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in part due to its geographic and cultural isolation, where historical records describe a migration of European settlers, primarily from Ireland and England, to NL in the 18th and 19th centuries. Whilst its historical isolation, and increased prevalence of certain monogenic disorders are well appreciated, details of the fine-scale genetic structure and ancestry of the population are lacking. Understanding the genetic origins and background of functional, disease causing, genetic variants would aid genetic mapping efforts in the Province.

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