Playing the Admission Game: Young People and Their Parents Negotiating Access or Discharge to Adolescent Inpatient Mental Health Services.

Background: Only children and young people with the highest need for mental health care or support are admitted to an inpatient setting. There has been a recent shift in emphasis with the aim of inpatient care being short and focussed, care is transferred back to the community on discharge. Little is known about what young people and their parents understand about admission and discharge criteria to these inpatient facilities.

Could the Inflation Reduction Act Maximum Fair Price Hurt Patients?

The Inflation Reduction Act's Medicare Drug Price Negotiation Program allows the federal government to negotiate caps for select medications. These price caps may reduce revenue for the pharmacy benefit managers (PBMs) that negotiate the actual price paid for medicines in the U.S.

Salmonella exploits membrane reservoirs for invasion of host cells.

Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish an intracellular replicative niche. A remarkable feature of Salmonella invasion is the formation of actin-rich protuberances (ruffles) on the host cell surface that contribute to bacterial uptake.

Modeling the Effects of Formulary Exclusions: How Many Patients Could Be Affected by a Specific Exclusion?

Medication formularies, initially designed to promote the use of cost-effective generic drugs, are now designed to maximize financial benefits for the pharmacy benefit management companies that negotiate purchase prices. In the second-largest pharmacy benefit management formulary that is publicly available, 55% of mandated substitutions are not for generic or biosimilar versions of the same active ingredient and/or formulation and may not be medically or financially beneficial to patients. We modeled the effect of excluding novel agents for atrial fibrillation/venous thromboembolism, migraine prevention, and psoriasis, which all would require substitution with a different active ingredient.

A fast parallelized DBSCAN algorithm based on OpenMp for detection of criminals on streaming services.

Introduction: Streaming services are highly popular today. Millions of people watch live streams or videos and listen to music.

Methods: One of the most popular streaming platforms is Twitch, and data from this type of service can be a good example for applying the parallel DBSCAN algorithm proposed in this paper.