Transcription factor 7-like 2 gene (TCF7L2) has been associated with type 2 diabetes. We investigated the association of the rs7903146 SNP in this gene with clinical profile of type 2 diabetes (T2DM) patients. The study involved 980 patients with diabetic nephropathy (44%), diabetic retinopathy (42%), CVD (65%) and early onset of diabetes (45%) and 924 healthy controls.
View Article and Find Full Text PDFHSPs (heat-shock proteins) are molecular chaperones synthesized under stress conditions, and are involved in renal cell survival and matrix remodelling in acute and chronic renal diseases. In the present study, we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy.
View Article and Find Full Text PDFMeasurements were performed before and after hemodialysis (HD) in the supine and upright positions (orthostatic change test) and during HD session every 30 minutes in recumbent position on 11 HD patients. Two hydration states were compared: hyperhydration and normal hydration. Each patient served as his own control.
View Article and Find Full Text PDFBackground: One of the uncertainties in the prescription of dialysis dose, measured as Kt/V for urea (Kt/Vu), is the volume of urea distribution (V). The aim of our study was to compare two different approaches to estimating V and Kt/V, respectively, and to compare the predicted (prescribed) dose with the actually delivered dose, measured by urea kinetics.
Material/methods: V was estimated using anthropometric measures with the Watson formula (VWatson), and also by multi-frequency bioimpedance analysis (VBIS).
Ann Univ Mariae Curie Sklodowska Med
December 2003
The bioimpedance technique is postulated as not expensive and non-invasive method for measurement of body water compartments in humans. However, the accuracy of the whole body bioimpedance technique has been questioned by several authors because of nonhomogenic nature of the human body. In the present study we used the whole body bioimpedance technique in comparison to segmental measurement from the arm and leg for assessment of extracellular water compartment.
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