Strongly oversized fission yeast cells lack any size control and tend to grow linearly rather than bilinearly.

During the mitotic cycle, the rod-shaped fission yeast cells grow only at their tips. The newly born cells grow first unipolarly at their old end, but later in the cycle, the 'new end take-off' event occurs, resulting in bipolar growth. Photographs were taken of several steady-state and induction synchronous cultures of different cell cycle mutants of fission yeast, generally larger than wild type.

Spirocycles as Rigidified sp-Rich Scaffolds for a Fragment Collection.

Novel divergent methodology to access sp-rich spirocyclic fragments is reported. First, a robust modular synthesis of bis-alkene amino ester building blocks was developed. Three different carbocycles and six heterocycles were then constructed to assemble eight spirocycles.

How do fission yeast cells grow and connect growth to the mitotic cycle?

To maintain size homeostasis in a unicellular culture, cells should coordinate growth to the division cycle. This is achieved via size control mechanisms (also known as size checkpoints), i.e.

Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase.

Background Information: Because cylindrically shaped fission yeast cells grow exclusively at their tips, cell volume is proportional to length and can be easily monitored by time-lapse microscopy. Here, we analysed the growth pattern of individual cells from several fission yeast strains to determine the growth function that describes them most adequately and to perform size control studies.

Results: The growth pattern of most cells during their growth period is best described by a bilinear function (i.