Publications by authors named "A Suvarnamani"
Article Synopsis
- A study in a malaria-endemic village in southeastern Thailand assessed the effectiveness of circumsporozoite (CS) antibodies as an indicator of malaria transmission through a 25-month monitoring period.
- The levels of CS antibodies increased during peak transmission periods and decreased during non-transmission seasons, aligning with patterns observed in traditional malaria measurement methods.
- Unlike asexual blood stage antibodies, which remained constant, CS antibodies varied with age and were responsive to environmental conditions and mosquito activity, making them a valid marker for understanding malaria transmission dynamics.
The circumsporozoite (CS) protein on the surface of sporozoites is the major target for antibody response(s) to the infective stage of the malaria parasite. Sera from malaria endemic areas contain both IgM and IgG antibodies that react with a dominant epitope in the tetrapeptide repeat region of the CS protein. In order to characterize the IgM CS antibody response in Plasmodium falciparum (PF) malaria, a prospective study was conducted in Thai Rangers.
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