Publications by authors named "A Surowka"
Article Synopsis
- Modern lifestyle diseases like diabetes and obesity affect millions globally, with GLP-1 receptor agonists (GLP-1RAs) emerging as significant treatments due to their broader influence on metabolic disorders.
- Evidence suggests GLP-1RAs might impact the thyroid and pancreas, raising concerns over their long-term safety, particularly regarding pancreatitis and thyroid tumors.
- The review highlights the importance of frequent monitoring for patients using GLP-1RAs, especially those at higher risk for these conditions.
Article Synopsis
- - Toxic milk (txJ) is a genetic mutation in the Atp7b gene found in a specific strain of mice, leading to symptoms similar to human Wilson's disease, and the study investigates the effects of this mutation on organ health over time.
- - Using advanced spectroscopy techniques, researchers found elevated copper levels in several organs (like the liver and brain) of txJ mice, along with significant alterations in lipid content and protein structure, which suggests underlying damage.
- - The findings indicate that txJ mice serve as an effective model for studying Wilson's disease, highlighting how copper accumulation can lead to tissue injury and neurodegeneration.
The Effect of Chronic Immunosuppressive Regimen Treatment on Apoptosis in the Heart of Rats.
Pharmaceuticals (Basel)
September 2024
Chronic immunosuppressive therapy is currently the only effective method to prevent acute rejection of a transplanted organ. Unfortunately, the expected effect of treatment brings a number of grave side effects, one of the most serious being cardiovascular complications. In our study, we wanted to investigate how treatment with commonly used immunosuppressive drugs affects the occurrence of programmed cardiac cell death.
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- - A 23-year-old woman experienced symptoms such as weakness in her left arm, numbness in her fingers, and cold sensations, leading to the diagnosis of arterial thoracic outlet syndrome (aTOS).
- - Thermal imaging was utilized as a diagnostic tool, helping to guide her treatment and ultimately leading to successful surgery and symptom improvement.
- - This case highlights thermal imaging as a rapid, effective, and radiation-free method for diagnosing vascular diseases related to blood flow issues, suggesting a promising direction for future clinical research.
Using different three-drug immunosuppressive treatment regimens in a rat model, we aimed to determine the effects of long-term therapy on metalloproteinase-2 and metalloproteinase-9 activity and the expression of their inhibitors, as well as to assess the morphology of the animals' cardiac tissue. Our results suggest that chronic use of immunosuppressive drugs disrupts the balance between the activity of MMPs and TIMPs. Depending on the type of drug regimen used, this leads to abnormalities in the cardiac structure, collagen fiber accumulation, or cardiomyocyte hypertrophy.
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