Dairy Cows Are Limited in Their Ability to Increase Glucose Availability for Immune Function during Disease.

Shortages of energy and glucose have been hypothesized to play a key role in the development of and responses to production diseases in dairy cows during early lactation. Given the importance of glucose for immune functions, we used a recently established method for the estimation of glucose balance (GB) to evaluate glucose availability during disease phases. A dataset comprising ration analyses as well as individual daily milk yields (MY), dry matter intake (DMI), body weights, and health records of 417 lactations (298 cows) was used to calculate individual daily GB and energy balance (EB).

Estimation of direct and maternal genetic effects and annotation of potential candidate genes for weight and meat quality traits in a genotyped outdoor dual-purpose cattle breed.

With regard to potential applications of genomic selection in small numbered breeds, we evaluated genomic models and focused on potential candidate gene annotations for weight and meat quality traits in the local Rotes Höhenvieh (RHV) breed. Traits included 6,003 birth weights (BWT), 5,719 200 d-weights (200dw), 4,594 365 d-weights (365dw), and 547 records for intramuscular fat content (IMF). A total of 581,304 SNP from 370 genotyped cattle with phenotypic records were included in genomic analyses.

Inter- and Intra-Individual Variation in the Behavior of Feed Intake on Nutrient Availability in Early Lactating Dairy Cows.

Since energetic deficits in dairy cows can only be reduced at an animal level, the objective of the present study was to determine the extent of variation in intake behavior within and between animals during early lactation, to explore the magnitude of interactions between feed intake, intake behavior and nutrient digestibility, and to identify levers for maximizing feed intake at the individual animal level. Feeding behavior, intake and nutrient digestibility of 28 German Holstein dairy cows, fed TMR with 7.0 MJ NEL, were studied between the 2nd and 15th week after calving.

Mismatch of Glucose Allocation between Different Life Functions in the Transition Period of Dairy Cows.

Immune cell functions such as phagocytosis and synthesis of immunometabolites, as well as immune cell survival, proliferation and differentiation, largely depend on an adequate availability of glucose by immune cells. During inflammation, the glucose demands of the immune system may increase to amounts similar to those required for high milk yields. Similar metabolic pathways are involved in the adaptation to both lactation and inflammation, including changes in the somatotropic axis and glucocorticoid response, as well as adipokine and cytokine release.

Relationships between feeding and microbial faeces indices in dairy cows at different milk yield levels.

A study was carried out to gain quantitative information on the diet-dependent faecal microbial biomass of dairy cows, especially on the biomass fractions of fungi, Gram-positive (G+) and Gram-negative (G-) bacteria. Groups of high-yield, low-yield and non-lactating cows were investigated at four different farms. A mean faecal microbial biomass C (MBC) concentration of 33.