Synthesis and Stereochemical Characterization of a Novel Chiral α-Tetrazole Binaphthylazepine Organocatalyst.

A novel α-tetrazole-substituted 1,1'-binaphthylazepine chiral catalyst has been synthesized and its absolute configuration has been determined by DFT computational analysis of the vibrational circular dichroism (VCD) spectrum of its precursor. The VCD analysis, carried out through the model averaging method, allowed to assign the absolute configuration of a benzylic stereocenter in the presence of a chiral binaphthyl moiety. The 1,1'-binaphthylazepine tetrazole and the nitrile its immediate synthetic precursor, have been preliminarily tested as chiral organocatalysts in the asymmetric intramolecular oxa-Michael cyclization of 2-hydroxy chalcones for the synthesis of chiral flavanones obtaining low enantioselectivity.

Erenumab Discontinuation After 12-Month Treatment: A Multicentric, Observational Real-Life Study.

Objective: To assess migraine outcome after 12-month treatment with erenumab and compare patients who underwent 3-month erenumab discontinuation following the first treatment cycle with those who continued monthly administrations.

Methods: This is a multicentric observational study in patients with migraine in treatment with erenumab. After a full 12-month treatment cycle (T), patients could either continue or discontinue erenumab for at least 3 months.

Effects of focal vibration on power and work in multiple wingate tests.

The aim of the study was to assess the effects of a specific protocol, based on a focal muscle vibration, on mechanical parameters in an exercise composed of five repeated bouts of sprint interval tests (Wingate Anaerobic Tests, 10 seconds duration). Twenty-eight young male healthy subjects were randomized to two groups (VIB and CTRL). Peak power (PP), average peak between bouts (aP) and total exercise work (TW) were measured.

Detection of parvovirus and herpesvirus DNA in the blood of feline and canine blood donors.

With the increase of blood transfusion in veterinary medicine, the presence of endemic viral agents in the blood should be carefully investigated. For this reason, the blood of feline and canine blood donors was screened to detect the presence of herpesviruses, especially gammaherpesviruses and parvoviruses, and to characterize the viruses detected. A retrospective cross-sectional study was performed on 31 cats and 54 dogs, enrolled as voluntary blood donors.