Publications by authors named "A Sulakvelidze"
Article Synopsis
- The PACIFIC study examined the presence of Adherent-Invasive E. coli (AIEC) in Crohn's disease patients from France and Hong Kong, finding similar prevalence rates (24.5% in France vs. 30.0% in Hong Kong).
- Antibiotic resistance was notably higher in AIEC strains from Hong Kong, particularly against multiple antibiotics, compared to those from France.
- All AIEC strains from both regions showed sensitivity to an EcoActive™ phage cocktail, indicating potential for this treatment to be effective globally against AIEC in Crohn's disease.
Article Synopsis
- Bacterial gastrointestinal diseases, particularly those caused by various Shigella species, lead to significant health issues globally, causing approximately 125 million cases of shigellosis and 14,000 deaths each year, mostly in young children in developing nations.
- A Phase 1 clinical trial evaluated the safety and tolerability of a new treatment called ShigActive™, a lytic bacteriophage aimed at Shigella, comparing its effects with a placebo over 29 days.
- Results showed that ShigActive™ was generally safe and well tolerated, with mild side effects reported by some participants and no serious adverse events, indicating it could be a potential option for treating shigellosis
Article Synopsis
- The text discusses the serious threat posed by a deadly bacterial pathogen responsible for numerous plague pandemics, causing over 200 million deaths, and highlights the urgent need for new treatment methods due to emerging antibiotic-resistant strains.
- The study evaluates a bacteriophage cocktail called YPP-401, which demonstrated around 88% effectiveness in protecting against pneumonic plague in rats when administered post-exposure.
- With no FDA-approved vaccines for the plague and the rise of antibiotic-resistant strains, phage therapy is presented as a promising alternative that could effectively combat infections, including those from multidrug-resistant pathogens.
, one of the deadliest bacterial pathogens ever known, is responsible for three plague pandemics and several epidemics, with over 200 million deaths during recorded history. Due to high genomic plasticity, is amenable to genetic mutations as well as genetic engineering that can lead to the emergence or intentional development of pan-drug resistant strains. The dissemination of such strains could be catastrophic, with public health consequences far more daunting than those caused by the recent COVID-19 pandemic.
View Article and Find Full Text PDFThe focus of this meeting was to discuss the suitability of using bacteriophages as alternative antimicrobials in the agrifood sector. Following a One Health approach, the workshop explored the possibilities of implementing phage application strategies in the agriculture, animal husbandry, aquaculture, and food production sectors. Therefore, the meeting had gathered phage researchers, representatives of the agrifood industry, and policymakers to debate the advantages and potential shortcomings of using bacteriophages as alternatives to traditional antimicrobials and chemical pesticides.
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