Preliminary reference values for Alzheimer's disease plasma biomarkers in Congolese individuals with and without dementia.

Background: Western countries have provided reference values (RV) for Alzheimer's disease (AD) plasma biomarkers, but there are not available in Sub-Saharan African populations.

Objective: We provide preliminary RV for AD and other plasma biomarkers including amyloid- (Aβ42/40), phosphorylated tau-181 and 217 (p-tau181, p-tau217), neurofilament light (Nfl), glial fibrillary acidic protein (GFAP), interleukin 1b and 10 (IL-1b and IL-10) and tumor necrosis factor (TNFα) in Congolese adults with and without dementia.

Methods: 85 adults (40 healthy and 45 dementia) over 50 years old were included.

Moving milk and shifting risk: A mixed methods assessment of food safety risks along informal dairy value chains in Kisumu, Kenya.

Animal sourced foods (ASF) are important for global food security and in mitigating the impact of undernutrition. Across Sub-Saharan Africa, demand and urbanization continue to increase, creating a greater divide between farm-level production and consumption. Food safety residues including antibiotics and aflatoxin residues often originate at the production site, and risk can shift as milk is transported.

Case-crossover designs and overdispersion with application to air pollution epidemiology.

Over the last three decades, case-crossover designs have found many applications in health sciences, especially in air pollution epidemiology. They are typically used, in combination with partial likelihood techniques, to define a conditional logistic model for the responses, usually health outcomes, conditional on the exposures. Despite the fact that conditional logistic models have been shown equivalent, in typical air pollution epidemiology setups, to specific instances of the well-known Poisson time series model, it is often claimed that they cannot allow for overdispersion.

New2Neuropsychology (N2N): An organization to promote diversity, equity, and inclusion in neuropsychology.

Objective: To introduce New2Neuropsychology (N2N), an organization that seeks to increase recruitment of historically underrepresented minoritized (URM) students, and to examine preliminary data on N2N's impact and effectiveness in increasing knowledge about neuropsychology for URM students.

Method: This paper reviews relevant literature on factors informing the development of N2N. We also present descriptive data on N2N's impact to date, and results of pre- and post- surveys for presentations about neuropsychology delivered to 90 college students (mean age = 24.

A Cryptic Prophage Transcription Factor Drives Phenotypic Changes via Host Gene Regulation.

Cryptic prophages (CPs) are elements of bacterial genomes acquired from bacteriophage that infect the host cell and ultimately become stably integrated within the host genome. While some proteins encoded by CPs can modulate host phenotypes, the potential for Transcription Factors (TFs) encoded by CPs to impact host physiology by regulating host genes has not been thoroughly investigated. In this work, we report hundreds of host genes regulated by DicC, a DNA-binding TF encoded in the Qin prophage of .