Publications by authors named "A Strazzulla"
Background And Aims: Alcohol-related liver disease (ALD) is one of the leading causes of severe liver disease with limited pharmacological treatments for alcohol-related steatohepatitis (ASH). CD44, a glycoprotein mainly expressed in immune cells, has been implicated in multiple inflammatory diseases but has never been studied in the ALD context. We therefore studied its contribution to ASH development in mice and its expression in ALD patients.
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- Monocytes play a crucial role in atherosclerosis by turning into macrophages when they migrate to plaques, and this study explores how their glucose metabolism influences their behavior and contribution to the disease.
- Researchers found that higher serum glucose levels are linked to increased monocyte numbers, while restricted diets hinder monocytes from switching energy sources, which reduces their presence in the blood.
- The study highlights that glucose metabolism is vital for maintaining specific monocyte characteristics and functions, but inhibiting glucose uptake alone doesn't prevent atherosclerosis, likely because the remaining monocytes become more migratory.
Stress exposure has been shown to modulate innate and adaptive immune responses. Indeed, stress favors myelopoiesis and monocyte generation and contributes to cardiovascular disease development. As sex hormones regulate innate and adaptive immune responses, we decided to investigate whether stress exposure leads to a different immune response in female and male mice.
View Article and Find Full Text PDFObjectives: To investigate the factors associated with isolates in intensive care unit (ICU) before and after an antimicrobial stewardship program.
Materials: Monocentric retrospective cohort study. Patients admitted to the ICU in 2007-2014 were included.
Background: Antibiotic selection pressure in human medicine is a significant driver of antibiotic resistance in humans. The primary aspect of antibiotic consumption is associated with general practitioner (GP) prescriptions. We aimed to identify prescriber profiles for targeted antimicrobial stewardship programs using novel indicators.
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