Publications by authors named "A Stefaniak"
This is the protocol for a Campbell systematic review. The objectives are as follows. (1) Examine whether secondary and tertiary interventions delivered outside of the criminal justice system are effective at countering the cognitive and behavioural radicalisation of children and adolescents by synthesising evidence relating to relevant primary and secondary outcomes of effectiveness.
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- - The study aimed to evaluate a new mouse model with a humanized Toll-like receptor-4 (hTLR-4) to investigate nickel allergy by assessing how it affects skin sensitization in mice.
- - Mice with the hTLR-4 receptor were exposed to nickel sulfate and showed significantly higher immune responses, including increased lymph node cellularity and elevated levels of IgE and various cytokines compared to hTLR-4-negative mice.
- - Results indicate that the hTLR-4 mouse model is more susceptible to nickel sensitization, making it a promising tool for future research on nickel allergy and its mechanisms.
Article Synopsis
- - This review focuses on basal cell carcinoma (BCC) that develops in scar tissue, noting its rarity but clinical importance, and includes a specific case involving a patient with a BCG vaccination scar.
- - It highlights the unclear mechanisms behind BCC growth associated with injury while emphasizing the need for further research to identify risk factors and improve understanding.
- - The review discusses various treatment options for BCC, including surgery and new medications, and stresses the need for regular skin assessments in patients with scars or recent vaccinations to enhance early detection and management.
Article Synopsis
- Anhedonia, the reduced ability to feel pleasure, is commonly seen in psychiatric disorders but hasn't been studied much in dermatological conditions like chronic itch, which is the focus of this study.
- The researchers examined 137 patients and found that about 13.1% showed signs of anhedonia, particularly those suffering from severe itch, and discovered that anhedonia was significantly linked to higher itch severity, anxiety, depression, and decreased quality of life.
- The findings suggest that addressing anhedonia could improve both mental health and treatment effectiveness for chronic itch, highlighting the need for future research to understand the connections further and create targeted interventions.
Article Synopsis
- The research focuses on practices related to changing scalpel blades when excising multiple skin lesions during the same appointment, particularly how beliefs about the risk of iatrogenic seeding (spreading cancer cells) influence these practices.* -
- A survey conducted with 173 medical specialists showed that surgeons tend to change blades more often than non-surgeons, with most citing concerns about seeding and training as reasons for their practices.* -
- The study concludes that while there's no strong scientific backing for regularly changing blades, significant differences in blade-changing practices exist among medical specialties, highlighting the need for standardizing evidence-based methods to improve patient care.*