Publications by authors named "A Stavrakis"
Article Synopsis
- The study investigates chronic periprosthetic joint infection (PJI) after joint replacements, focusing on how a special irrigant can disrupt the biofilm covering the implant and enhance microbial detection.
- Researchers compared two methods (culture and Next Generation Sequencing) to identify microbes in samples from 38 Total Knee Arthroplasty patients before and after irrigation with the Bactisure Lavage.
- Results showed a decrease in detectable organisms with culture techniques post-lavage, while NGS identified many more microbes (177 vs. 126) afterward, including 135 organisms not detected before, indicating a hidden diversity of microbes in the biofilm.
Article Synopsis
- This study investigated TRL1068, a monoclonal antibody designed to tackle chronic periprosthetic joint infections (PJI) caused by biofilms, in 15 patients.
- TRL1068 was given as a single pre-surgical infusion in three different doses, in addition to targeted antibiotics, and showed a favorable safety profile with no adverse events linked to the treatment.
- Results indicated a significant reduction in implant bacteria in 3 out of 11 patients receiving TRL1068, with no relapses of infection by day 169, suggesting it could be a promising option for PJI treatment.
This work presents a novel approach towards integrating electronic components with textiles, by successfully creating a fully textile-based element that is capable of detecting applied forces by variation in its resistance value. The fabrication of the device consists of a specialized siliconized conductive fabric, which is placed above and below a layer of switch fabric, which acts as a force sensor. In this paper, the effects of three different geometries are observed, as well as the washability of the device, along with tension testing.
View Article and Find Full Text PDFPurpose: Dislocation remains 1 of the leading causes of revision after primary total hip arthroplasty (THA) and there is clear evidence the dual-mobility (DM) is used more frequently to minimise this. But in smaller cups, whether the use of DM with smaller 22-mm heads imparts any increased stability compared to standard bearing is unknown; especially when those smaller cups now allow for large single-bearing (SB) heads.
Methods: 3 primary cup sizes (48 mm, 50 mm, 52 mm) were chosen for modelling.
Point-of-Care Coating of Revision Femoral Stems With Antibiotic-Loaded Calcium Sulfate: Reduction in Infection After 2nd Stage Reimplantation but Not With Aseptic Revisions.
Arthroplast Today
February 2024
Background: Infection rates in revision total hip arthroplasty are lower when antibiotic loaded cemented stems are utilized. Inspired by this technique, a point-of-care coating of antibiotic-loaded calcium sulfate (CaSO) was applied to cementless revision stems in aseptic revision and 2nd stage reimplantation total hip arthroplasty.
Methods: One hundred eleven consecutive femoral stems were coated.