Publications by authors named "A Staruschenko"
Endoplasmic Reticulum-Associated Degradation: A Novel Therapeutic Avenue for ADPKD.
Am J Physiol Cell Physiol
January 2025
Diabetic kidney disease (DKD) is the leading cause of chronic renal pathology. Understanding the molecular underpinnings of DKD is critical to designing tailored therapeutic approaches. Here, we focused on sex differences and the contribution of aging toward the progression of DKD.
View Article and Find Full Text PDFPodocytes are specialized cells within the glomerular filtration barrier, which are crucial for maintaining glomerular structural integrity and convective ultrafiltration. Podocytes exhibit a unique arborized morphology with foot processes interfacing by slit diaphragms, ladder-like, multimolecular sieves, which provide size and charge selectivity for ultrafiltration and transmembrane signaling. Podocyte dysfunction, resulting from oxidative stress, dysregulated prosurvival signaling, or structural damage, can drive the development of proteinuria and glomerulosclerosis in hypertensive nephropathy.
View Article and Find Full Text PDFArticle Synopsis
- Cannabinoids, derived from the Cannabis plant, are used both medically and recreationally, with THC and CBD being prominent examples, but their effects on peripheral organs like the kidneys need more research.
- * The review highlights the relationship between the endocannabinoid system and kidney function, exploring how cannabinoids might be involved in kidney diseases and their therapeutic potential.
- * Additionally, the review addresses the harmful effects of cannabinoids on kidney health and their link to negative cardiovascular outcomes, emphasizing the need for further understanding in these areas.
Article Synopsis
- - The study highlights the important function of the K5.1 potassium channel (KCNJ16) in regulating electrolyte balance and blood pressure, with previous research showing its mutations can lead to health issues like hypokalemia and renal problems.
- - Researchers discovered a new variant, I26T, in an Amish patient, who experienced symptoms like polydipsia and metabolic acidosis, and then developed an animal model to better understand this mutation.
- - Findings from the rat model showed that the I26T variant did not significantly affect blood pressure, electrolyte levels, or renal function compared to normal rats, suggesting it may be a benign mutation rather than a harmful one.