Publications by authors named "A Starosta"

In the spore-forming bacterium Bacillus subtilis transcription and translation are uncoupled and the translational machinery is located at the cell poles. During sporulation, the cell undergoes morphological changes including asymmetric division and chromosome translocation into the forespore. However, the fate of translational machinery during sporulation has not been described.

View Article and Find Full Text PDF

Objectives: Lidocaine patches are a common topical analgesic therapy but have not been thoroughly investigated in the surgical or obstetric literature. We sought to investigate the impact of adding topical lidocaine patches to routine postcesarean pain management on patients' postcesarean pain scores and opioid use.

Study Design: This is a prospective randomized subject-blinded controlled trial of patients undergoing cesarean delivery at a single institution.

View Article and Find Full Text PDF

Introduction With the advancement of artificial intelligence, large language models (LLMs) have emerged as technology that can generate human-like text across various domains. They hold vast potential in the dental field, able to be integrated into clinical dentistry, administrative dentistry, and for student and patient education. However, the successful integration of LLMs into dentistry is reliant on the dental knowledge of the models used, as inaccuracies can lead to significant risks in patient care and education.

View Article and Find Full Text PDF
Article Synopsis
  • Ribosomal function is enhanced by trans-acting factors and ribosomal elements, with phosphorylation playing a key regulatory role.
  • The ribosomal P-stalk, which consists of five phosphorylated C-terminal domains, activates translational GTPases and connects to the Gcn2 kinase within the integrated stress response (ISR) pathway.
  • Unlike most ribosomal proteins, P-stalk proteins remain in a constantly phosphorylated state, promoting optimal translation efficiency and allowing flexible interaction with various protein partners.
View Article and Find Full Text PDF

The transcriptional control of sporulation in Bacillus subtilis is reasonably well understood, but its translational control is underexplored. Here, we use RNA-seq, ribosome profiling and fluorescence microscopy to study the translational dynamics of B. subtilis sporulation.

View Article and Find Full Text PDF