Publications by authors named "A Starke"
Current lifestyles are leading to a worldwide increase in metabolic liver diseases that favor the development of liver disease. Changes in hepatocytes are caused by altered lipid concentrations, oxidative stress or toxicity by individual lipids. The complexity of the underlying processes and differences of the pathology to proposed rodent models makes the development of an effective targeted therapy difficult.
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- - A 4th lactation dairy cow had complications after an unsuccessful treatment for a left displaced abomasum (LDA) using the "blind-stitch" method, leading to abnormal health signs and inflammation at the incision site.
- - After administering antibiotics and fluids, the cow underwent a laparotomy and omentopexy surgery to resolve adhesion issues, and was monitored before being discharged two weeks later.
- - The cow produced 18,000 kg of milk post-treatment, with total costs for both interventions at 1,207 €, alongside an estimated revenue loss of 4,168 € due to complications, highlighting the need for careful method selection for LDA corrections.
Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial.
Br J Anaesth
November 2024
Background: This study aimed to assess whether a driving pressure-limiting strategy based on positive end-expiratory pressure (PEEP) titration according to best respiratory system compliance and tidal volume adjustment increases the number of ventilator-free days within 28 days in patients with moderate to severe acute respiratory distress syndrome (ARDS).
Methods: This is a multi-centre, randomised trial, enrolling adults with moderate to severe ARDS secondary to community-acquired pneumonia. Patients were randomised to a driving pressure-limiting strategy or low PEEP strategy based on a PEEP:FiO table.
Severe acute ischemic stroke (AIS) is mainly caused by thromboembolism originating from symptomatic carotid artery (ICA) stenosis or in the heart due to atrial fibrillation. Glycoprotein VI (GPVI), a principal platelet receptor, facilitates platelet adherence and thrombus formation at sites of vascular injury such as symptomatic ICA stenosis. The shedding of GPVI from the platelet surface releases soluble GPVI (sGPVI) into the circulation.
View Article and Find Full Text PDFBackground: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear.
Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia.