Droperidol has comparable clinical efficacy against both nausea and vomiting.

Background: Droperidol is commonly noted to be more effective at preventing postoperative nausea (PON) than vomiting (POV) and it is assumed to have a short duration of action. This may be relevant for clinical decisions, especially for designing multiple-drug antiemetic regimens.

Methods: We conducted a post hoc analysis of a large multicentre trial.