Effectiveness of Suprathel® application in partial thickness burns, frostbites and Lyell syndrome treatment.

Unlabelled: The skin is the largest organ of the human body consisting of several layers possessing different properties and performing different physiological functions. The loss of skin integrity caused by a trauma or disease may provoke acute physiological and immune disorders that may even be fatal. The following properties are primarily taken into account when choosing the appropriate burn wound dressing: support of the epithelialisation process, pain and patient discomfort reduction, and treatment costs.

Metabolic and monocyte-suppressing actions of fenofibrate in patients with mixed dyslipidemia and early glucose metabolism disturbances.

The aim of this study was to compare the action of fenofibrate on monocyte cytokine release between patients with isolated mixed dyslipidemia and dyslipidemia coexisting with prediabetic states in relationship with its metabolic actions.We compared 96 primary mixed dyslipidemic patients and 29 age-, sex- and weight-matched control subjects with normal lipid profile. Depending on glucose metabolism, dyslipidemic patients were allocated into one of three treatment groups: isolated dyslipidemia, dyslipidemia coexisting with impaired fasting glucose (IFG) and dyslipidemia coexisting with impaired glucose tolerance (IGT).

[Proatherogenic lipid metabolism disturbances in impaired glucose tolerance].

The role of Impaired Glucose Tolerance (IGT) in the pathogenesis of cardiovascular complications is still underestimated. Besides proven doubled risk of diabetes mellitus, IGT patients present wide range of atherogenic disturbances such as insulin resistance, proinflammatory and procoagulant state and proatherogenic lipid changes. This paper reviews lipid metabolism disorders, such as elevation of free fatty acids and triglycerides level, structural changes of LDL (high level of "small dense" and modified LDL), HDL particles and more, as well as visceral obesity often observed in patients with IGT.

Monocyte suppressing action of fenofibrate.

Since atherosclerosis has been proven to be an inflammatory disease, it is obvious that the proper treatment for dyslipidemia should not only correct lipid parameters but also inhibit inflammation. Monocytes and monocyte-derived proinflammatory cytokines are widely known to be involved in the formation and rupture of the atherosclerotic plaque. The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia.

The risk of atherosclerosis in patients with impaired glucose tolerance.

Objectives: Glucose metabolism disorders usually coexist with dyslipidemia and coagulation/fibrinolysis disturbances. Increase of insulin resistance followed by hyperinsulinemia leads to enhanced protein synthesis, including production of apolipoproteins. As a result, the structure of Low Density Lipoprotein (LDL) becomes small and dense.