Publications by authors named "A St-Pierre"
Age is an important risk factor of stroke, cognitive decline, and dementia. Senescent endothelial cells (ECs) accumulate with advancing age through exposure to cellular stress, such as that exerted by hypertension and diabetes. These senescent ECs have altered characteristics, such as altered tight junction proteins, use of a more indiscriminate transcellular transport system, increased inflammation, and increased immune cell interactions.
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- Recent population studies suggest that viral infections, like influenza and COVID-19, may increase the risk of ischemic stroke, although the exact mechanisms remain unclear.
- The review highlights how interactions between viruses and hosts can directly affect vascular function, inflammation, and thrombosis, contributing to stroke incidence.
- It emphasizes the need for more research to understand these mechanisms better and encourages the development of targeted prevention strategies for stroke linked to viral infections.
In REACH4, a phase 1/2, open-label, single-arm, multicenter study, the pharmacokinetics (PK), efficacy, and safety of ruxolitinib were evaluated in treatment-naïve and steroid-refractory pediatric patients with grade 2 to 4 acute graft-versus-host disease (aGVHD; n = 45). Ruxolitinib dosing was based on age and targeted the exposure in adults receiving 10 mg twice daily; group 1 (aged ≥12 to <18 years) received 10 mg twice daily and preliminary starting doses for groups 2 (aged ≥6 to <12 years) and 3 (aged ≥2 to <6 years) were 5 mg twice daily and 4 mg/m2 twice daily, respectively. The phase 1 primary objective was to assess ruxolitinib PK parameters and define an age-appropriate recommended phase 2 dose (RP2D) for patients aged <12 years.
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- Heart failure due to heat stress is a significant concern for aquatic ectotherms, and mitochondrial dysfunction may play a key role in this issue.
- The study focused on the thermal sensitivity of cardiac mitochondria in three-spined stickleback fish, examining factors like temperature, fatty acid composition, and age.
- Results showed that while temperature strongly affected mitochondrial respiration, fish age also influenced it, revealing higher EPA levels in older fish but no direct correlation with critical thermal maximum (CTmax).
Background: Chronic graft-versus-host disease (GVHD) is a debilitating, and sometimes life threatening, complication of allogeneic haematopoietic stem-cell transplantation (HSCT). We aimed to investigate the activity, pharmacokinetics, and safety of ruxolitinib added to corticosteroids in paediatric patients (ie, <18 years) with moderate-to-severe chronic GVHD.
Methods: In this single-arm, phase 2 study, patients were recruited at 21 hospitals or clinics across 14 countries in Asia, Europe, and Canada.