Publications by authors named "A St Georges"
Environmental DNA (eDNA) analysis has become a popular conservation tool for detecting rare and elusive species. eDNA assays typically target mitochondrial DNA (mtDNA) due to its high copy number per cell and its ability to persist in the environment longer than nuclear DNA. Consequently, the development of eDNA assays has relied on mitochondrial reference sequences available in online databases, or in cases where such data are unavailable, de novo DNA extraction and sequencing of mtDNA.
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- The near-complete mitogenome sequence of the Chelodina intergularis holotype suggests that it is actually synonymous with Chelodina rugosa.
- The type specimens for both species are located in the Australian Museum in Sydney, and historical records indicate their type locality is near Somerset, Queensland.
- The study concludes that the unique arrangement of scutes in C. intergularis is likely just an individual anomaly rather than a distinct characteristic of the species.
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a co-receptor for NGF and tropomyosin-related kinase A (TrkA) pain signaling. NRP1 was coexpressed with TrkA in human and mouse nociceptors.
View Article and Find Full Text PDFThe spectral and transport properties of strongly correlated metals, such as SrVO_{3} (SVO), are widely attributed to electron-electron (e-e) interactions, with lattice vibrations (phonons) playing a secondary role. Here, using first-principles electron-phonon (e-ph) and dynamical mean field theory calculations, we show that e-ph interactions play an essential role in SVO: they govern the electron scattering and resistivity in a wide temperature range down to 30 K, and induce an experimentally observed kink in the spectral function. In contrast, the e-e interactions control quasiparticle renormalization and low temperature transport, and enhance the e-ph coupling.
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- Malignant hyperthermia (MH) is a serious genetic condition triggered by certain anesthetics, particularly affecting a protein called RyR1.
- Dantrolene is the main treatment for MH, but how it works and where it binds on RyR1 was previously unclear.
- This study used cryo-electron microscopy to detail how dantrolene and another agent bind to RyR1, revealing that dantrolene's binding requires ATP or ADP and can close the channel, highlighting its potential role in sensing energy levels in cells.