Improved resolution of avian influenza virus using Oxford Nanopore R10 sequencing chemistry.

Unlabelled: Highly pathogenic avian influenza viruses continue to pose global risks to One Health, including agriculture, public, and animal health. Rapid and accurate genomic surveillance is critical for monitoring viral mutations, tracing transmission, and guiding interventions in near real-time. Oxford Nanopore sequencing holds promise for real-time influenza genotyping, but data quality from R9 chemistry has limited its adoption due to challenges resolving low-complexity regions such as the biologically critical hemagglutinin cleavage site, a homopolymer of basic amino acids that distinguish highly pathogenic strains.

Real World Outcomes with Treatment Free Remission in Chronic Myeloid Leukemia-Experience from a Tertiary Care Cancer Centre.

Chronic myeloid leukaemia (CML) is caused by balanced translocation t(9::22)(q34;q11) resulting in formation of pathogenic BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML. Ongoing treatment with TKI leads to side effects and has financial impact.

Improving Palliative Care Research Reporting: A Guide to Reporting Guidelines.

Improving the quality of research reporting is crucial for addressing current challenges in palliative care, with academic journals playing a crucial role in promoting clear and comprehensive reporting through structured guidelines. These guidelines, such as Appraisal of Guidelines, Research, and evaluation, Consolidated Standards of Reporting Trials, Case Reports (CARE) guidelines, transparent reporting of evaluations with nonrandomized designs (TREND), transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD), meta-analysis of observational studies in epidemiology (MOOSE) Checklist, methods of researching end-of-life care Statement, Preferred Reporting Items for Systematic Reviews and Meta-analyses, Standards for Quality Improvement Reporting Excellence 2.0, Strengthening the Reporting of Observational Studies in Epidemiology, standard protocol items: recommendations for interventional trials (SPIRIT), template for intervention description and replication (TIDieR) Consolidated Criteria for Reporting Qualitative Research and Standards for Qualitative Research, are instrumental in ensuring transparency by furnishing essential details for comprehending, replicating and applying research findings in clinical decision-making and systematic reviews.

Evaluation of Soft Tissue Changes Following Orthognathic Surgery Using Virtual Surgical Planning Software.

Context: Orthognathic surgery brings about a harmonious relationship between jaws, resulting in improved facial aesthetics. It is key to analyze if satisfactory results can be attained by using virtual surgical planning for orthognathic procedures so as to recommend it for routine clinical practice.

Aims: The aims of this study were to evaluate the various soft tissue changes that take place following orthognathic surgery using three-dimensional (3D) imaging and virtual surgical planning software and quantify the accuracy of virtual surgical planning software on patients undergoing orthognathic surgery.

GPU optimization techniques to accelerate optiGAN-a particle simulation GAN.

The demand for specialized hardware to train AI models has increased in tandem with the increase in the model complexity over the recent years. Graphics processing unit (GPU) is one such hardware that is capable of parallelizing operations performed on a large chunk of data. Companies like Nvidia, AMD, and Google have been constantly scaling-up the hardware performance as fast as they can.