Publications by authors named "A Spyroglou"
Immunohistochemical expression of ephrin receptors in neuroendocrine neoplasms: a case-series of gastroenteropancreatic neuroendocrine neoplasms and a systematic review of the literature.
Endocrine
October 2024
Article Synopsis
- The study investigates the expression of Erythropoietin-producing hepatocellular (EPH) receptors in neuroendocrine neoplasms (NENs), which are significant in various biological processes including tumor growth and spread.
- Immunohistochemical analysis of tumor samples from 30 patients showed varying levels of expression for different EPH subtypes, with high positivity rates for EPH-A4 and EPH-A5.
- The findings suggest that EPH receptors could play a crucial role in the development and treatment of NENs, highlighting their potential as targets for new therapeutic strategies.
Article Synopsis
- - Macrophages are vital for maintaining specific functions and balance in the adrenal gland, particularly in regulating aldosterone production through their interactions with blood vessels.
- - The study reveals that the absence of the molecule VEGF-A in macrophages leads to changes in blood vessel structure, resulting in increased aldosterone secretion and associated health issues like high blood pressure.
- - Findings suggest that the communication between macrophages and endothelial cells is crucial for adrenal health and could have significant implications for understanding similar processes in other endocrine organs.
Background: Poorly differentiated thyroid carcinoma (PDTC) has an intermediate prognosis between indolent well-differentiated thyroid carcinoma (TC) and anaplastic carcinoma. Herein, we present a case report with a PDTC component, along with a systematic review of the literature.
Case Report: We report a case of a 45-year-old man diagnosed with a PDTC component, along with hobnail and tall-cell variant features positive for BRAFV600E mutation, after a total thyroidectomy and neck dissection.
Background: Clinical practice guidelines recommend the Lateralization Index (LI) as the standard for determining surgical eligibility in primary aldosteronism (PA). Our goal was to identify the optimal LI cut-offs in adrenal venous sampling (AVS) for diagnosing PA that is amenable to surgical cure.
Methods: We conducted a retrospective international cohort study across 16 institutions in 11 countries, including 1,550 patients with PA who underwent AVS, with and/or without ACTH stimulation.
Article Synopsis
- Von-Hippel-Lindau (VHL) is a genetic disorder that leads to tumors and cysts in various organs, and this case discusses a 23-year-old woman with VHL who developed rare gastric neuroendocrine tumors (gNENs) while also suffering from chronic autoimmune gastritis (CAG).
- The gNENs observed in this patient showed characteristics similar to those typically seen in VHL-related tumors, despite gNENs not being commonly associated with VHL.
- The findings suggest that the formation of clear-cell gNENs might be influenced more by CAG rather than just VHL, highlighting the importance of careful monitoring of such tumors in patients before ruling out VHL disease