Publications by authors named "A Spyridaki"
The process of aging leads to a progressive decline in the immune system function, known as immunosenescence, which compromises both innate and adaptive responses. This includes impairments in phagocytosis and decreased production, activation, and function of T- and B-lymphocytes, among other effects. Bacteria exploit immunosenescence by using various virulence factors to evade the host's defenses, leading to severe and often life-threatening infections.
View Article and Find Full Text PDFAntibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs. This review focuses on the mechanisms underlying resistance in key bacterial pathogens and highlights how aging-related factors like immunosenescence, frailty, and multimorbidity increase the burden of infections from MDROs in this population. Novel strategies to mitigate resistance include the development of next-generation antibiotics like teixobactin and cefiderocol, innovative therapies such as bacteriophage therapy and antivirulence treatments, and the implementation of antimicrobial stewardship programs to optimize antibiotic use.
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- - As the population ages, older adults (65+) are undergoing more surgeries, which leads to increased risks due to health issues like comorbidities, polypharmacy, and frailty.
- - Traditional risk assessment tools often fail to predict post-operative outcomes for the elderly, but Comprehensive Geriatric Assessment (CGA) effectively identifies patients at risk for complications such as delirium and infections.
- - CGA not only predicts risks but also aids in tailoring personalized perioperative care, improving surgical outcomes and preventing functional decline among older patients.
Article Synopsis
- This study examines mortality trends in Greece from 2001 to 2020, highlighting the impact of the COVID-19 pandemic, particularly in an aging population, which can inform health policies in other similar societies.
- Data on deaths and population were analyzed using age-standardized mortality rates (ASMR) and cause-specific rates across different age groups, revealing significant trends in cardiovascular diseases and other major causes of death.
- Findings showed a notable decrease in ASMR for cardiovascular diseases, although hypertensive diseases rose significantly; the leading causes of death shifted based on age, emphasizing the need for updated health strategies in response to these trends.
This study investigates the forecasting of cardiovascular mortality trends in Greece's elderly population. Utilizing mortality data from 2001 to 2020, we employ two forecasting models: the Autoregressive Integrated Moving Average (ARIMA) and Facebook's Prophet model. Our study evaluates the efficacy of these models in predicting cardiovascular mortality trends over 2020-2030.
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