Publications by authors named "A Spuler"
Corrigendum to "Detection and analysis of cerebral aneurysms based on X-ray rotational angiography - the CADA 2020 challenge" [Medical Image Analysis, April 2022, Volume 77, 102333].
Matthias Ivantsits Leonid Goubergrits Jan-Martin Kuhnigk Markus Huellebrand Jan Bruening Andreas Spuler
Med Image Anal
February 2025
Objectives: Assessing the risk associated with unruptured intracranial aneurysms (IAs) is essential in clinical decision making. Several geometric risk parameters have been proposed for this purpose. However, performance of these parameters has been inconsistent.
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- The CADA challenge aimed to improve algorithms for detecting and analyzing cerebral aneurysms in 3D rotational angiography images by providing training on 109 anonymized datasets and testing on 22 additional ones.
- Participants from 22 countries created detection solutions primarily using U-Net, achieving a high F2 score of 0.92, which is comparable to expert performance, though smaller aneurysms were sometimes missed.
- The challenge also assessed rupture risk estimation, with the best methods combining various parameters to achieve an F2 score of 0.70, closely matching the 0.71 score when using expert-defined structures.
Autosomal dominant cerebral cavernous malformations (CCM) are leaky vascular lesions that can cause epileptic seizures and stroke-like symptoms. Germline mutations in either CCM1, CCM2 or CCM3 are found in the majority of patients with multiple CCMs or a positive family history. Recently, the first copy number neutral inversion in CCM2 has been identified by whole genome sequencing in an apparently mutation-negative CCM family.
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- Skeletal muscle stem cells, known as satellite cells and marked by PAX7, are crucial for muscle growth and recovery after injury.
- Previous efforts to harness these muscle stem cells for therapy have not succeeded, but the existence of human PAX7-positive cell colonies with high regenerative abilities has been confirmed.
- Researchers also found PAX7-negative muscle-derived cells that can still regenerate muscle and express other markers; these cells can restore the satellite cell niche and even re-express PAX7, indicating muscle regeneration does not solely rely on PAX7.