Publications by authors named "A Sponaas"
Obesity is associated with an increased risk of developing multiple myeloma (MM). The molecular mechanisms causing this association is complex and incompletely understood. Whether obesity affects bone marrow immune cell composition in multiple myeloma is not characterized.
View Article and Find Full Text PDFBackground: Multiple myeloma (MM) is an incurable malignancy of plasma cells. The serine protease matriptase is frequently dysregulated in human carcinomas, which facilitates tumor progression and metastatic dissemination. The importance of matriptase in hematological malignancies is yet to be clarified.
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- The study analyzed genomic and transcriptomic changes in 29 multiple myeloma patients pre- and post-treatment, revealing that 82% showed changes in clonal composition and a rise in single-nucleotide variants (SNVs) from 67 to 86.
- Notable increases in genetic abnormalities were observed in RAS genes, amp1q21, and TP53, with a specific mutation signature found regardless of melphalan dosage.
- Differential gene expression analysis showed significant pathway changes linked to increased proliferation and metabolism in late-stage disease, highlighting several potentially targetable genes.
Cancer cells can convert proto-oncoproteins into oncoproteins by increasing the expression of genes that are oncogenic when expressed at high levels. Such genes can promote oncogenesis without being mutated. To find overexpressed genes in cancer cells from patients with multiple myeloma, we retrieved mRNA expression data from the CoMMpass database and ranked genes by their expression levels.
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