Publications by authors named "A Spinelli"
Key steps in exposure techniques for robotic total mesorectal excision (TME).
Tech Coloproctol
December 2024
Aim: The use of robotic surgery is increasing significantly. Specific training is fundamental to achieve high quality and better oncological outcomes. This work defines key exposure techniques in robotic total mesorectal excision (TME).
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- The study aims to provide updated evidence for managing stage I colon cancer (CC) post-surgery, focusing on recurrence rates and risk factors.
- Despite low recurrence risk, some guidelines suggest intensive follow-up is unnecessary, but data on actual recurrence rates is limited.
- The findings reveal a 5% recurrence rate, primarily systemic, with significant risk factors including tumor characteristics and patient demographics, suggesting a need for improved postoperative follow-up strategies.
Objective: To evaluate the outcome of teeth filled with a single cone technique and a premixed bioceramic sealer at 3 years of follow-up.
Methods: Healthy patients were consecutively treated by a cohort of postgraduate operators. Root canal filling procedures were performed with NiTi rotary instrumentation, while non-surgical retreatments were performed using NiTi reciprocating instruments.
Article Synopsis
- There has been a concerning rise in early-onset colorectal cancer (EO-CRC) cases, prompting research into how prognosis compares to late-onset colorectal cancer (LO-CRC).
- A systematic review of 26 studies found that EO-CRC patients are more likely to be diagnosed at advanced stages, yet they have better overall survival rates compared to LO-CRC patients, while other survival metrics like cancer-specific survival remain similar.
- The study highlights the need for better early detection methods for EO-CRC due to the differences in stage at diagnosis between the two groups.
Arrayed CRISPR libraries extend the scope of gene-perturbation screens to non-selectable cell phenotypes. However, library generation requires assembling thousands of vectors expressing single-guide RNAs (sgRNAs). Here, by leveraging massively parallel plasmid-cloning methodology, we show that arrayed libraries can be constructed for the genome-wide ablation (19,936 plasmids) of human protein-coding genes and for their activation and epigenetic silencing (22,442 plasmids), with each plasmid encoding an array of four non-overlapping sgRNAs designed to tolerate most human DNA polymorphisms.
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