Publications by authors named "A Sourla"
Determination of microsatellite instability (MSI)/mismatch repair (MMR) status in cancer has several clinical implications. Our aim was to integrate MSI/MMR status from patients tested in Greece to assess the prevalence of MSI-high (MSI-H)/deficient MMR (dMMR) per tumor type, testing patterns over time and concordance between MSI and MMR status. We retrospectively recorded MSI/MMR testing data of patients with diverse tumor types performed in pathology and molecular diagnostics laboratories across Greece.
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- Proteus syndrome (PS) is a rare genetic disorder caused by mutations in the AKT1 or PTEN genes, leading to uneven tissue growth, while sinonasal neuroendocrine carcinomas (SNEC) are extremely rare tumors found in the nasal and ethmoid cavities.
- A 35-year-old PS patient had a successful surgical removal of a well-differentiated SNEC obstructing his nasal cavity, illustrating the importance of teamwork among healthcare professionals to ensure safe airway management and effective treatment.
- This case represents the first report of SNEC in a PS patient, suggesting a potential link between the conditions due to shared genetic pathways involving AKT1 variants.
Ectopic or accessory breast tissue may occur in primitive embryonic milk lines or locations other than the milk line. The same pathology arising in breast tissue may occur less frequently in ectopic breast tissue. Fibroadenomas rarely occur in ectopic breast tissue, with less than 50 reported cases in the English literature, despite being the most common benign breast neoplasms.
View Article and Find Full Text PDFParagangliomas are rare lesions of the endocrine system that can be treated either by embolization preoperatively followed by surgical excision or by surgical excision or radiotherapy. In this report, we present an extremely rare location of a nonfunctional paraganglioma in the head and neck region, located in the right supraclavicular fossa, which was misdiagnosed as a thyroid tumor, in a 72-year-old female patient. Imaging revealed a 2.
View Article and Find Full Text PDFBackground: Menetrier's disease is a rare hyperproliferative protein-losing gastropathy of the gastric foveolar epithelium. It is characterized by giant hypertrophic folds, excess mucus secretion, decreased acid secretion and hypoproteinemia due to selective loss of serum proteins across the gastric mucosa. The discovery of transforming growth factor-α overexpression opened the way of epidermal growth factor receptor blockade with cetuximab as first-line treatment modality for Menetrier's disease.
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