Publications by authors named "A Soulier"
Severe coronavirus disease 2019 (COVID-19) is related to dysregulated immune responses. We aimed to explore the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on the immune response by nasopharyngeal transcriptomic in critically-ill patients. This prospective monocentric study included COVID-19 patients requiring intensive care unit (ICU) admission between March 2020 and 2022.
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- RSV infection is a significant cause of pneumonia in adults, but its genetic diversity and clinical outcomes are not well understood.
- A study of 100 hospitalized RSV patients from January 2019 to December 2022 found that 72 were infected with RSV-B, and the severity of infection did not correlate with genetic clustering.
- Patients with RSV-B and risk factors for severe pneumonia showed greater fusion protein diversity, but no mutations linked to resistance to the treatment nirsevimab were identified.
Background: Microbiological diagnosis of intrauterine infections (IIU) still relies on bacteriological cultures or targeted DNA amplification lacking in sensitivity. Shotgun metagenomics (SMg) is an emerging unbiased molecular approach that makes it possible to sequence all the nucleic acids from any sample. It had never previously been used for IIU.
View Article and Find Full Text PDFHepatitis of undetermined origin can be caused by a wide variety of pathogens, sometimes emerging pathogens. We report the discovery, by means of routine shotgun metagenomics, of a new virus belonging to the family Circoviridae, genus Circovirus, in a patient in France who had acute hepatitis of unknown origin.
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- A study investigated the prevalence of unusual HCV genotype 1 subtypes in patients who did not achieve sustained virological response after first-line antiviral treatment, focusing on a population with significant representation from sub-Saharan Africa.
- Among 640 treatment failures, 7.3% involved patients with these unusual genotypes, who exhibited genetic polymorphisms leading to reduced effectiveness of direct-acting antivirals.
- The findings suggest that while these patients are less likely to respond to initial treatment, retreatment with a specific combination of antiviral drugs is usually effective in achieving a cure.