Publications by authors named "A Soufan"
Research Question: What is the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE)?
Design: This prospective longitudinal cohort study was carried out between 2007 and 2015.
Results: Around 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia and 3% of men with NOA needed testosterone replacement therapy (TRT). Klinefelter syndrome was strongly associated with TRT while no association was found between obstructive azoospermia or NOA and TRT.
Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort.
Hum Reprod
March 2023
Study Question: What is the impact of cancer or hematological disorders on germ cells in pediatric male patients?
Summary Answer: Spermatogonial quantity is reduced in testes of prepubertal boys diagnosed with cancer or severe hematological disorder compared to healthy controls and this reduction is disease and age dependent: patients with central nervous system cancer (CNS tumors) and hematological disorders, as well as boys <7 years are the most affected.
What Is Known Already: Fertility preservation in pediatric male patients is considered based on the gonadotoxicity of selected treatments. Although treatment effects on germ cells have been extensively investigated, limited data are available on the effect of the disease on the prepubertal male gonad.
Study Question: Is intracervical insemination (ICI) non-inferior to IUI with cryopreserved donor sperm in the natural cycle in terms of live birth?
Summary Answer: ICI with cryopreserved donor sperm in the natural cycle was inferior to IUI in terms of live birth.
What Is Known Already: Both ICI and IUI in the natural cycle are performed as first-line treatments in women who are eligible for donor sperm treatment. High-quality data on the effectiveness of ICI versus IUI with cryopreserved donor sperm in the natural cycle in terms of live birth is lacking.
Study Question: Do parental characteristics and treatment with ART affect perinatal outcomes in singleton pregnancies?
Summary Answer: Both parental and ART treatment characteristics affect perinatal outcomes in singleton pregnancies.
What Is Known Already: Previous studies have shown that singleton pregnancies resulting from ART are at risk of preterm birth. ART children are lighter at birth after correction for duration of gestation and at increased risk of congenital abnormalities compared to naturally conceived children.
Study Question: What is the semen quality in trans women at time of fertility preservation, prior to the start of gender-affirming hormone treatment?
Summary Answer: Before the start of gender-affirming hormone treatment, semen quality in trans women was already strongly decreased compared to the general population.
What Is Known Already: Hormone treatment for -trans women (birth-assigned males, female gender identity) consists of anti-androgens combined with estrogens in order to achieve feminization and it is accompanied by a loss of reproductive capability. Trans women can opt for semen cryopreservation prior to their medical transition to retain the possibility to parent genetically related offspring.