Dupilumab in chronic rhinosinusitis with nasal polyposis and concomitant cystic fibrosis: a real-life experience.

Purpose: Chronic rhinosinusitis (CRS) has been distinguished in primary CRS, a primary inflammatory disorder limited to airways and secondary CRS, in which the sinonasal pathology is caused by a systemic disease or a local pathologic condition. Primary CRS is in turn classified in Type 2 and Non-type 2 on the basis of the endotype and of the pattern of the immune response. Advance in the knowledge of CRS has led to new therapeutic options, among which Dupilumab (anti-IL4R).

The Effect of Myofascial Stretching on Mechanical Nociception and Contributing Neural Mechanisms.

Myofascial stretching is often prescribed in the management of musculoskeletal pain. However, the neural mechanisms contributing to a decrease in pain are unknown. Stretching produces a sensation that may act as a conditioning stimulus in a conditioned pain modulation response.

Factors correlated with hearing aids adherence in older adults: a prospective controlled study.

Objective: To investigate which factors influence the adherence to hearing aid (HA) use in elderly patients with moderate-to-severe hearing loss.

Methods: This observational, prospective, single-centre study enrolled patients with moderate-to-severe hearing loss. They were evaluated before and 1 year after having either one or two HAs fitted.

-based determination of lanthanoid-radical exchange as visualised by inelastic neutron scattering.

Magnetic exchange coupling can modulate the slow magnetic relaxation in single-molecule magnets. Despite this, elucidation of exchange coupling remains a significant challenge for the lanthanoid(iii) ions, both experimentally and computationally. In this work, the crystal field splitting and 4f-π exchange coupling in the erbium-semiquinonate complex [ErTpdbsq] (Er-dbsq; Tp = hydro-tris(1-pyrazolyl)borate, dbsqH = 3,5-di--butyl-1,2-semiquinone) have been determined by inelastic neutron scattering (INS), magnetometry, and CASSCF-SO calculations.

Supportive error feedback fosters students' adaptive reactions towards errors: Evidence from a targeted online intervention with Italian middle school students.

Background: Although it is well established that students' adaptive reactions towards errors promote learning outcomes, little is still known about the role of error feedback in promoting these reactions.

Aim: Through a targeted intervention based on an online teaching unit, this study aimed at testing whether supportive error feedback promotes more adaptive students' reactions towards errors and higher learning outcomes.

Sample: A total of 250 (M   = 12.