Publications by authors named "A Somell"
Background: Optimal sampling is critical for the performance of blood cultures (BCs). Most guidelines recommend collecting 40 ml of blood, divided between two venipuncture sites, i.e.
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- In sepsis, a high release of inflammatory cytokines occurs, but the exact cellular source is still unclear.
- Researchers used a specific technique to analyze cytokine production from blood cells in 32 septic patients and 30 healthy controls, finding that septic patients had fewer cytokine-secreting cells in response to LPS stimulation.
- The findings suggest that circulating leukocytes are not responsible for the elevated plasma cytokine levels seen in sepsis, indicating a complex regulation of cytokine secretion related to the severity of the condition.
Monocytes have long been considered a heterogeneous group of cells both in terms of morphology and function. In humans, three distinct subsets have been described based on their differential expression of the cell surface markers CD14 and CD16. However, the relationship between these subsets and the production of cytokines has for the most part been based on ELISA measurements, making it difficult to draw conclusions as to their functional profile on the cellular level.
View Article and Find Full Text PDFBackground: Hyperbiliverdinaemia is a poorly defined clinical sign that has been infrequently reported in cases of liver cirrhosis or liver carcinoma, usually indicating a poor long-term prognosis.
Aims: To clarify the pathogenesis of hyperbiliverdinaemia in an extended case report.
Methods: A 64-year-old man with alcoholic cirrhosis was admitted to hospital with severe bleeding from oesophageal varices.
Aim: To evaluate the haemodynamic effects of the dual endothelin receptor antagonist tezosentan, both alone and combined with hypertonic saline/dextran (HSD), on porcine endotoxin shock, with focus on cardiopulmonary circulation. The effects on gas exchange and short-term survival were also studied.
Methods: A prospective, randomized experimental study was carried out.