Publications by authors named "A Soman"
Introduction: Pregestational diabetes mellitus (PGDM) occurs when a woman becomes pregnant after having diabetes mellitus. The presence of diabetes during the entire pregnancy can have an adverse impact on fetal and neonatal outcomes. The objective of this study is to examine the association between PGDM and neonatal outcomes at birth.
View Article and Find Full Text PDFEarly-onset colorectal cancer (EOCRC), recognized as a distinct subgroup with an increased incidence over the past two decades, characterized by its aggressive nature and potentially unique molecular factors that differentiate it from traditional colorectal cancer (CRC). In this study, we investigated differentially expressed genes in a young-CRC patient using paired-end mRNA-sequencing. Validation of target genes through qRT-PCR highlighted a significant increase in SERPINA3 levels in EOCRC, representing a novel finding.
View Article and Find Full Text PDFFemale hypospadias is an extremely rare condition characterised by urethral meatus placed within the introitus on the anterior vaginal wall, along with foreshortening of the urethra. It is an often missed anomaly that usually co-exists with other genitourinary conditions like ectopic ureter, renal anomalies, septate vagina and bicornuate uterus. A case series of five girls who had hypospadias is being described.
View Article and Find Full Text PDFArticle Synopsis
- Chromatin phase separation is influenced by factors like post-translational modifications and plays a key role in genomic functions, but the exact mechanisms are still not well understood.
- The study utilized modified solid-state NMR techniques to investigate dynamic components in phosphorylated heterochromatin protein 1α (pHP1α) and found that different NMR methods can provide insights into molecular dynamics within phase-separated systems.
- Results showed that lower KCl concentrations (30 mM) reduced molecular motion in the protein gel, whereas higher concentrations (150 mM) increased motion due to changes in intermolecular electrostatic interactions.
Objective: The study employed three-dimensional (3D) finite element analysis (FEA) and examined how implant diameters affect stress distribution across the implant-bone contact and how stress transmission through this interface changes during axial and non-axial loading.
Materials And Methods: A 3D mandibular model was created using cone beam CT of a patient with implants inserted into the first mandible molar. Nobel Biocare implants (Nobel Biocare, Switzerland) with specific dimensions of 3.