Pump depletion and the Raman gap in ignition-scale plasmas.

Laser-plasma instabilities under ignition conditions for direct-drive inertial confinement fusion are studied using two-dimensional particle-in-cell simulations with a combination of in-plane (PP) and out-of-the-plane (SP) lasers. The results show that stimulated Raman side-scattering can induce significant pump depletion and form a gap in the Raman scattered-light spectra that have been observed in experiments.

[Artificial ventilation in patients with stroke: main results of the Russian multicenter observational clinical trial RETAS].

Objective: To analyze the relationship between the characteristics of respiratory support (RS) for patients with stroke and clinical factors with the number and structure of complications, deaths, and length of stay in the intensive care unit (ICU) and duration of artificial pulmonary ventilation (ALV).

Material And Methods: The Russian multicenter observational clinical study «Respiratory Therapy for Acute Stroke» (RETAS) that enrolled 1289 patients with stroke requiring RS was conducted under the auspices of the All-Russian public organization «Federation of Anesthesiologists and Resuscitators». Indications for ALV, the use of hyperventilation, the maximum level of positive end-expiratory pressure, starting modes of mechanical ventilation, timing of tracheostomy, the incidence of protein-energy malnutrition (PEM) and infectious complications were analyzed.

Evaluation of serum and urine biomarkers for severe COVID-19.

Introduction: The new coronavirus disease, COVID-19, poses complex challenges exacerbated by several factors, with respiratory tissue lesions being notably significant among them. Consequently, there is a pressing need to identify informative biological markers that can indicate the severity of the disease. Several studies have highlighted the involvement of proteins such as APOA1, XPNPEP2, ORP150, CUBN, HCII, and CREB3L3 in these respiratory tissue lesions.

Hot-electron preheat and mitigation in polar-direct-drive experiments at the National Ignition Facility.

Target preheat by superthermal electrons from laser-plasma instabilities is a major obstacle to achieving thermonuclear ignition via direct-drive inertial confinement fusion at the National Ignition Facility (NIF). Polar-direct-drive surrogate plastic implosion experiments were performed on the NIF to quantify preheat levels at an ignition-relevant scale and develop mitigation strategies. The experiments were used to infer the hot-electron temperature, energy fraction, and divergence, and to directly measure the spatial hot-electron energy deposition profile inside the imploding shell.