Publications by authors named "A Snowman"
Article Synopsis
- Synapses connect neurons to form networks that process information, and their function relies on adaptable molecular components regulated by cell adhesion signaling.
- The enzyme biliverdin reductase (BVR) plays a crucial role by linking important signaling molecules at the synapse, affecting learning and memory.
- Without BVR, critical kinases fail to activate necessary receptors for synaptic plasticity, leading to significant deficits in neurocognitive functions and disruptions in synaptic signaling pathways in the hippocampus.
Article Synopsis
- * Recent findings indicate a more powerful action of cocaine, suggesting the existence of a high-affinity receptor for cocaine, specifically associated with brain acid soluble protein 1 (BASP1).
- * Knocking down BASP1 in the striatum reduces cocaine binding and depleting it in the nucleus accumbens decreases locomotion in mice, indicating BASP1's importance as a receptor for cocaine.
Alzheimer's disease (AD), the most common cause of dementia and neurodegeneration in the elderly, is characterized by deterioration of memory and executive and motor functions. Neuropathologic hallmarks of AD include neurofibrillary tangles (NFTs), paired helical filaments, and amyloid plaques. Mutations in the microtubule-associated protein Tau, a major component of the NFTs, cause its hyperphosphorylation in AD.
View Article and Find Full Text PDFBilirubin is one of the most frequently measured metabolites in medicine, yet its physiologic roles remain unclear. Bilirubin can act as an antioxidant in vitro, but whether its redox activity is physiologically relevant is unclear because many other antioxidants are far more abundant in vivo. Here, we report that depleting endogenous bilirubin renders mice hypersensitive to oxidative stress.
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