Assessment of whole body MRI and sestamibi technetium-99m bone marrow scan in prediction of multiple myeloma disease progression and outcome: a prospective comparative study.

Objectives: This study aims primarily to determine whether whole body MRI (WB-MRI) and Sestamibi Technetium-99m-bone marrow (MIBI) scans in the same patients produce the same estimate of disease load and location, and secondly, to study possible association between the bone disease detected by these scans and the effect on disease outcome and survival. Bone disease occurs in about 90% of multiple myeloma (MM) patients. There are no data comparing the new diagnostic modalities with WB-MRI and MIBI in MM.

Radionuclide venography: two stage--flow and equilibrium technique using 99mTc pertechnetate, and 99mTc RBC labelled "in vivo".

A new method involves 2 stages: 1st, injection of three 10 ml boluses of 99mTc-pertechnetate through a dorsal vein of the foot with recording of 3 separate dynamic studies of venous flow in the calf, thigh and pelvis; and 2nd, static equilibrium venography (EV), which can be completed 15 min later after 99mTc-RBC labelling in vivo. The method was performed in 100 patients with suspected DVT. Due to the large pertechnetate bolus followed with 20-40 ml flush of normal saline, the flow study provides a significant improvement in filling of major calf veins, which makes this technique more similar to contrast phlebography.

(Na-K)ATPase activity along the nephrons in normal and adrenalectomized rats measured by quantitative cytochemistry.

A cytochemical method was used to measure total, ouabain insensitive and specific (Na-K)ATPase activities along the rat nephron. Enzyme activity was expressed as per cent of mean integrated extinction with reference to a calibrated filter. The lowest mean values of total, ouabain-insensitive, and (Na-K)ATPase activities were found in the proximal convoluted tubule (PCT).

Thyroxine turnover and transport in viral hepatitis.

Thyroxine turnover and transport studies were done on 20 patients in the acute phase of viral hepatitis. No significant changes in T4 degradation rate (k), the T4 distribution volume (V), and the metabolic clearance rate (MCR) were found. A significant increase of T4 serum concentration and TBG capacity, and decrease of TBPA capacity were observed.