Improvements in quality of life over 2 years with cladribine tablets in people with relapsing multiple sclerosis: The CLARIFY-MS study.

Background: Multiple sclerosis (MS) negatively affects health-related quality of life (HRQoL).

Objective: To evaluate HRQoL in people with highly active relapsing MS treated with cladribine tablets (CladT; 3.5 mg/kg cumulative dose over 2 years) in CLARIFY-MS.

Difficulties in interpretation of oral food challenge results.

Oral food challenge is the gold standard in diagnosing food allergies; however, many testing protocols are available. The present article illustrates the difficulties associated with interpreting oral challenge tests with the example of a six-year-old boy with allergy to hen's eggs. The symptoms observed on the first day of challenge indicated a negative result; however, the consumption of the cumulative dose resulted in anaphylaxis.

Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth.

Enhancer of rudimentary (ER) is a small protein that has a unique amino acid sequence and structure. Its highly conserved gene has been found in all eukaryotic kingdoms with the exception of fungi. ER was proposed to be involved in the metabolism of pyrimidines and was reported to act as a transcriptional repressor in a cell type-specific manner.

[The effect of corneal incision method on astigmatism after cataract extraction].

Purpose: To assess the effect of the type of corneal incision and its closure on astigmatism after cataract extraction.

Material And Methods: Induced astigmatism was evaluated in 94 eyes after cataract extraction with IOL implantation 7 days, 1 month, 3 months, 6 months and 12 months after operation. 3 groups: were compared I--after extracapsular extraction with corneo-scleral incision (10 h-2 h) and continuous cross-like suture, II--after phacoemulsifications with scleral tunnel incision (3.