Publications by authors named "A Smrke"
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are tumors that come from specific cells in the gut and are primarily caused by certain genetic mutations; surgical removal is the best option for localized cases, while targeted drug therapies are the standard for management.
- Recent advances in understanding GISTs have led to updates in treatment strategies, but disparities in care exist across Canada due to its provincial healthcare system, highlighting the need for standardized guidelines.
- A panel of 20 experienced Canadian physicians from various specialties reviewed literature on GISTs to create a consensus on management practices, covering key topics like molecular profiling and multidisciplinary care to improve consistency in treatment across the country.
Article Synopsis
- * Histological analysis showed specific cell characteristics and confirmed the presence of the FUS::TFCP2 fusion, indicating a rare subtype of soft tissue sarcoma that can significantly influence treatment options.
- * The patient responded rapidly to the ALK inhibitor alectinib, but the response was short-lived due to the advanced stage of the disease, highlighting the need for targeted therapies in such rare cancer cases.
Objectives: We conducted a retrospective multi-centre study to assess the real-world outcome of regorafenib (REGO) and cabozantinib (CABO) in recurrent/refractory bone tumours (BTs) including osteosarcoma (OST), Ewing sarcoma (EWS) and chondrosarcoma (CS)/extra-skeletal mesenchymal CS (ESMC).
Methods: After regulatory approval, data from patients with recurrent BT (11 institutions) were extracted from CanSaRCC (Canadian Sarcoma Research and Clinical Collaboration) database. Patient characteristics, treatment and outcomes were collected.
Due to the rarity and complexity of treatment for Ewing sarcoma and rhabdomyosarcoma, studies demonstrate improved patient outcomes when managed by a multidisciplinary team at high-volume centres (HVCs). Our study explores the difference in outcomes of Ewing sarcoma and rhabdomyosarcoma patients based on the centre of initial consultation in British Columbia, Canada. This retrospective study assessed adults diagnosed with Ewing sarcoma and rhabdomyosarcoma between 1 January 2000 and 31 December 2020 undergoing curative intent therapy in one of five cancer centres across the province.
View Article and Find Full Text PDFBackground: Breast angiosarcoma may arise spontaneously (primary breast angiosarcoma (PBA)) or may arise secondary to a biological insult, such as radiation therapy (secondary breast angiosarcoma (SBA)). We evaluated the imaging findings of patients diagnosed with PBA and SBA within the province of British Columbia, Canada.
Materials And Methods: This was a multi-center, retrospective study of patients diagnosed with PBA and SBA over a 25-year period.