Publications by authors named "A Skorek"
Salivary gland tumors are rare head and neck tumors constituting up to 6% of all head and neck neoplasms; despite being mostly benign, these tumors present in diverse histological subtypes, making them challenging to diagnose and treat. Our research aims to investigate the link between inflammation and tumorigenesis within the salivary glands based on the literature regarding the etiopathogenesis of benign salivary gland tumors. This scoping review was conducted following the PRISMA extension for scoping reviews and reporting guidelines.
View Article and Find Full Text PDFArticle Synopsis
- Salivary gland tumors can present in various forms, and the WHO has categorized 22 malignant and 11 benign types, with diagnosis relying on imaging and biopsy techniques.
- A pilot study is exploring the use of peptide biomarkers in saliva to help diagnose these tumors, comparing samples from tumor tissues and healthy individuals.
- The research identified 109 peptides unique to tumor tissues and patients' saliva, but the lack of consistent peptides across samples suggests tumor variety and may indicate that tumors inhibit the production of specific salivary proteins.
High mortality, aggressiveness, and the relatively low effectiveness of therapy make melanoma the most dangerous of skin cancers. Previously published studies presented the promising therapeutic potential of minocycline, doxycycline, and chlortetracycline on melanoma cells. This study aimed to assess the cytotoxicity of tigecycline, a third-generation tetracycline, on melanotic (COLO 829) and amelanotic (A375) melanoma cell lines.
View Article and Find Full Text PDFNumerical and clinical analysis of an eyeball injuries under direct impact.
Int J Occup Med Environ Health
May 2023
Objectives: The objective of this study was to develop a numerical model of the eyeball and orbit to simulate a blunt injury to the eyeball leading to its rupture, as well as to conduct a comparative analysis of the results obtained using the finite element method against the clinical material concerning patients who had suffered an eyeball rupture due to a blunt force trauma.
Material And Methods: Using available sclera biometric and strength data, a numerical model of the eyeball, the orbital contents, and the bony walls were developed from the ground up. Then, 8 different blunt force injury scenarios were simulated.