Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity.

Background: The role of tumor necrosis factor alpha (TNF-alpha), one of the adipose tissue products, in the pathogenesis of insulin resistance is well-documented. Many recent studies have shown beneficial influence of L-arginine supplementation on cardiovascular system. However, molecular mechanisms of its positive actions are not fully elucidated.

The effect of oral L-arginine supplementation on fasting glucose, HbA1c, nitric oxide and total antioxidant status in diabetic patients with atherosclerotic peripheral arterial disease of lower extremities.

Introduction: Numerous studies indicate hyperglycemia and oxidative stress as factors responsible for endothelium dysfunction and the following development of angiopathy. Increased production of free radicals by vascular endothelium causes disturbance in production and/or decreases bioaccessibility of nitric oxide (NO). It has been suggested that L-arginine supplementation is a reasonable method to increase endothelium NO production and lower free radicals formation.

Supplementation with L-arginine does not influence arterial blood pressure in healthy people: a randomized, double blind, trial.

Background And Objectives: It cannot be excluded that supplementation with L-arginine, by improving function of endothelium and hypotensive effect, can be advantegeous in prevention of cardiovascular diseases in healthy people. However, reports about hypotensive effect of L-arginine in healthy people are unclear. Moreover, no research including ambulatory blood pressure measurement (ABPM) has been conducted so far.

[Adverse effects of glucocorticoids. Exacerbation of iatrogenic chronic adrenal failure in patient with acute coronary syndrome treated with glucocorticoids as a result of severe obstructive pulmonary disease. Case report].

The article prescribes short review of adverse effects of glucocorticoids on the basis of clinical case of exacerbation of iatrogenic adrenal failure in the course of acute coronary syndrome with ST elevation (ACS STEMI) in a patient with chronic obstructive pulmonary disease (COPD).

Twenty-four hour ambulatory blood pressure monitoring in young and elderly hypertensive subjects.

The aim of our study was to compare blood pressure (BP) measured by 24-h ambulatory monitoring in young and elderly hypertensives and to find a dependency between left ventricular mass (LVM) and different pressure ratios. We also estimated the calcium ionized concentration and serum lipids in all subjects. Two hypertensive groups divided accordingly by age were studied.