Publications by authors named "A Sithara"
The adaptive immune response critically hinges on the functionality of T cell receptors, governed by complex molecular mechanisms, including ubiquitination. In this study, we delved into the role of in T cell immunity, focusing on T cell-B cell conjugate formation and T cell activation. Using a CRISPR-Cas9 screening approach targeting deubiquitinases genes in Jurkat T cells, we identified BAP1 as a key positive regulator of T cell-B cell conjugate formation.
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- Novel drug discoveries are changing how hematological malignancies like multiple myeloma (MM) are treated, but MM remains incurable, highlighting the need for new therapies.
- Research has shown that abnormal pre-mRNA splicing is common in MM, and this study focuses on identifying these disease-specific changes and suggests RNA-based therapies to address them.
- A specific example examined is the abnormal splicing of the HMMR gene, where researchers found variations linked to splicing issues and proposed therapies to selectively target this abnormality, which could also be useful for other cancers.
Oral squamous cell cancers involving the masticatory space are staged as unresectable cancers and their treatment is difficult. Curative treatment with extensive surgery followed by adjuvant therapy is one of the treatment options. In this retrospective study, the survival of 123 patients (93 with T4a cancers, 30 with T4b cancers), treated during the period August 2009 to August 2015, was evaluated.
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