Publications by authors named "A Sisto"
Background: In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.
View Article and Find Full Text PDFPrevalence and impact of multidrug resistance in a cohort of patients admitted to emergency department for urinary tract-infections: The UTILY study, a prospective multicentre study.
Eur J Intern Med
December 2024
Background And Aim: The aim of the present study was to evaluate the prevalence and to identify the independent predictors of multi-drug resistance among a cohort of patients admitted to emergency department for urinary tract infections (UTI), and to assess the impact of antimicrobial resistance on the clinical outcomes.
Methods: We conducted a prospective multicentre study enrolling all adult patients admitted to one of the eight emergency departments participating in the study with a microbiologically confirmed diagnosis of UTI from February 2023 to July 2024. The primary outcome evaluated was 30-day mortality; secondary outcomes included 7-day mortality and clinical response.
HSPB1 [heat shock protein family B (small) member 1] and HSPB8 are essential molecular chaperones for neuronal proteostasis, as they prevent protein aggregation. Mutant HSPB1 and HSPB8 primarily harm peripheral neurons, resulting in axonal Charcot-Marie-Tooth neuropathies (CMT2). Macroautophagy/autophagy is a shared mechanism by which HSPB1 and HSPB8 mutations cause neuronal dysfunction.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the immune characteristics and viral makeup of young adults in Argentina who acquired HIV at birth (p-YA), comparing them to young adults with HIV acquired through other means.
- Researchers conducted a detailed examination of immune cell types and their functions using techniques like flow cytometry and ELISA, involving 18 p-YA and various control groups.
- Key findings revealed that p-YA had a unique immune profile with more naïve CD4 T-cells and lower signs of exhaustion, suggesting they face different challenges in managing the HIV virus compared to those who acquired it later in life.
Introduction: Previous animal-assisted interventions (AAI) studies have documented that human-animal interaction can reduce anxiety levels and improve social skills and quality of life. In recent decades there was a growing evidence on the benefits achievable through human-animal relationship in different categories of people, such as children with autism spectrum disorder, elderly patients affected by dementia, patients with psychiatric disorders and alcohol/drug addiction.
Methods: In the present study ten patients from psychiatric residential facilities belonging to the EPASSS Foundation were approached to participated in this study.