Publications by authors named "A Singh Soraisham"
Background: Our aim was to investigate the relationship between persistent pulmonary hypertension of the newborn (PPHN), short-term brain injury or death, and clinical parameters in infants with moderate to severe hypoxic ischemic encephalopathy (HIE).
Methods: Retrospective single-center cohort study of 274 HIE infants, 230 underwent Therapeutic Hypothermia (TH). Primary outcome was severe HIE brain injury on MRI and/or death within the first month of life in relation to presence and severity of PPHN (clinical or echocardiographic).
Background: Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85-95% within the first 10 min. Over the last 10 years, recommendations regarding the ideal level of the initial fraction of inspired oxygen (FiO) for resuscitation in preterm infants have changed from 1.0, to room air to low levels of oxygen (< 0.
View Article and Find Full Text PDFObjective: Intercenter variation and trends in postnatal steroids (PNS) use among preterm infants for prevention or treatment of bronchopulmonary dysplasia (BPD) is known. Understanding intracenter PNS use patterns facilitate implementation of center-specific change interventions to optimize outcomes.This study aimed to (i) quantify the proportion of infants who received PNS, and describe the timing, type, trends over time, regimen used, and deviations, and (2) describe the clinical characteristics and unadjusted outcomes of infants who received PNS.
View Article and Find Full Text PDFIn contrast to adults, neonates and infants with coronavirus disease 2019 (COVID-19) infection have milder symptoms and are less likely to require hospitalization. However, some neonates with COVID-19 can present with significant symptoms. Recent evidence suggests that neurologic manifestations of neonatal COVID-19 infection may be higher than initially thought.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the impact of inhaled nitric oxide (iNO) treatment on the neurodevelopmental outcomes of preterm neonates (born before 29 weeks) suffering from hypoxaemic respiratory failure.
- Researchers analyzed data from neonates born between 2010 and 2018, comparing those who received iNO in their first week of life with those who did not, focusing on outcomes measured at 18-24 months corrected age.
- The findings revealed that although the iNO group had more severe health issues and higher rates of complications, there was no significant difference in the likelihood of neurodevelopmental impairment among surviving infants treated with iNO compared to those not treated.