Publications by authors named "A Simonsen"
Article Synopsis
- Contact dermatitis is a frequent skin issue in children, resulting from exposure to irritants or allergens in their environment.
- Diagnosis involves assessing symptoms, dermatitis patterns, and a patient's exposure history, with patch testing being the most reliable method to differentiate allergic from irritant contact dermatitis.
- The review focuses on understanding contact dermatitis in children, covering how to diagnose it, differentiate it from other conditions, and strategies for managing it.
There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers.
View Article and Find Full Text PDFKlippel-Feil syndrome (KFS) is a rare congenital condition characterized by the fusion of cervical vertebrae. It classically presents with a triad of symptoms: limited cervical range of motion, a low posterior hairline, and a short neck. Common otolaryngological manifestations include hearing loss, dysphagia, cleft palate, jaw disorders, thyroid abnormalities, and ear malformations, highlighting the importance of KFS awareness in the field of otolaryngology.
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- Alzheimer's (AD) and Parkinson’s disease (PD) are major neurodegenerative disorders characterized by specific protein aggregations, with Alzheimer’s linked to amyloid-beta (Aβ) and tau, and Parkinson’s associated with alpha-synuclein (αSyn).
- The research examined naturally occurring autoantibodies (nAbs), including IgG, IgM, and IgA, in patients with AD, PD, and dementia with Lewy bodies (DLB), revealing altered levels and affinities of these antibodies compared to healthy controls.
- Findings indicated that AD patients had lower high-affinity anti-αSyn and anti-Aβ IgGs, while DLB patients showed increased anti-αSyn IgG but decreased Ig