Publications by authors named "A Simion"
Introduction: Lower respiratory tract infections, including COVID-19, have a substantial global impact, making the development of diagnostic tests crucial. The study aimed to develop a new, accurate, fast, and cost-effective PCR-based detection method for SARS-CoV-2, applicable in limited settings and capable of detecting all current variants and potential future pathogens.
Methods: The study was conducted between 2020 and 2022 at the molecular biology department of Mures County Clinical Hospital (MCCH), Romania.
Biofilm Formation and Antibiotic Resistance Profiles in Carbapenemase-Producing Gram-Negative Rods-A Comparative Analysis between Screening and Pathological Isolates.
Antibiotics (Basel)
July 2024
(1) Background: Carbapenem-resistant (CR) bacteria pose a significant global public health challenge due to their ability to evade treatment with beta-lactam antibiotics, including carbapenems. This study investigates the biofilm-forming capabilities of CR clinical bacterial isolates and examines the impact of serum on biofilm formation. Additionally, the study evaluates the resistance profiles and genetic markers for carbapenemase production.
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- Silibinin (SIL) from Silybum marianum has beneficial effects but suffers from low stability and bioavailability, prompting the research into its derivatives, silibilin oleate (SIL-O) and silibilin linoleate (SIL-L), as prodrugs for better biomedical applications.
- Characterization techniques like DFT calculations and NMR confirmed the successful formation of SIL-O and SIL-L, showing they have lower drug-likeness scores than SIL but still a positive overall drug score with no severe side effects expected.
- While SIL-O showed no toxicity at low concentrations, SIL-L was more toxic at high doses, particularly affecting certain cell types and demonstrating a slight irritant effect; thus,
Water is one of the fundamental resources for the existence of humans and the environment. Throughout time, due to urbanization, expanding population, increased agricultural production, and intense industrialization, significant pollution with persistent contaminants has been noted, placing the water quality in danger. As a consequence, different procedures and various technologies have been tested and used in order to ensure that water sources are safe for use.
View Article and Find Full Text PDFBackground: Over one-third of patients living with diabetes will develop ocular disease during their lifetime. The present study analyzes the association between metabolic and anthropometric markers, associated comorbidities, and intraocular pressure (IOP) in patients with type 2 diabetes mellitus (DM).
Methods: The retrospective study included 87 adult patients with type 2 DM who underwent routine eye examinations and blood/urine tests.