Publications by authors named "A Sim"
Article Synopsis
- The study examines the link between liver disease type (alcohol-related vs non-alcohol-related) and 6-week mortality following acute variceal bleeding (AVB) in patients with cirrhosis.
- Researchers analyzed data from two large cohorts in the U.S. and Singapore, including 1,349 patients, and found that non-ALD patients had a significantly higher risk of mortality compared to ALD patients.
- Incorporating the etiology of cirrhosis into existing mortality prediction models improved accuracy, highlighting the importance of considering the type of liver disease for patient care.
Article Synopsis
- The NOTCH2NLC gene is linked to several neurological disorders through expansions of GGC repeats in its 5' untranslated region, which can lead to conditions like Parkinson's, dementia, and tremors.
- The study used cellular models and CRISPR-Cas9 engineered mice with specific GGC repeat variations to investigate the effects of these repeats, particularly focusing on those with serine insertions.
- Results showed that a specific intermediate repeat with serine insertion caused mitochondrial dysfunction and neurotoxicity, leading to PD-like symptoms in mice, including neuronal loss and behavioral impairments.
Purpose: To evaluate the acceptability and feasibility of a consumer co-designed telehealth intervention which aimed to reduce claimant distress by providing pain management strategies, informational and social support to people who had made a compensation claim following road traffic musculoskeletal injury.
Methods: Eleven claimant participants who were at risk of a poor outcome completed the intervention in a one-on-one setting with the same clinician delivering the program across all sessions.They were interviewed about their experience (acceptability and feasibility including the use of telehealth).
Wernicke encephalopathy is an acute neuropsychiatry syndrome resulting from thiamine deficiency associated with significant morbidity and mortality. We reported a case of a 25-year-old woman with a history of abdomen pain, nausea, vomiting, weight loss, and sore throat who presented with acute neurological symptoms, including binocular diplopia, hearing loss, vision loss, and difficulty ambulating. Examination revealed bilateral vision loss with perception only to light, ophthalmoplegia, hearing loss, gait ataxia, and areflexia.
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