Sustainable synthesis of 1,2,3-triazoles using Cyrene as a biodegradable solvent in click chemistry.

The first successful synthesis of 1,2,3-triazoles using CyreneTM as a biodegradable and non-toxic solvent in click chemistry has been developed. In contrast to previous methods, this sustainable approach allows product isolation by simple precipitation in water, eliminating the need for organic solvent extractions and column chromatography purifications, thus minimizing waste consumption while reducing operational costs. The protocol, performed also at gram scale, has broad applicability and versatility, as shown with complex substrates like biologically active coumarins or triazole-linked bifunctional molecules.

The role of the circadian timing system in sarcopenia in old age: a scoping review.

Purpose: Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.

Wearable sensors for monitoring caregivers of people with dementia: a scoping review.

Purpose: Caregivers of people with dementia often face a demanding care burden that may lead to adverse physical and psychological outcomes. Wearable sensors are becoming a valuable tool for preventive care. We aimed to provide the first systematic map of the published evidence on the use of wearable sensors to monitor caregivers of people with dementia.

Choroid plexus tumors in adults: a retrospective mono-institutional study.

Purpose: Choroid plexus tumors (CPT) are rare entities, and even rarer in adulthood.

Methods: A retrospective consecutive series of 24 adult CPT patients was reviewed.

Results: We described 24 adult CPTs.