Prognostic significance of CD4 and interleukin-22 expression in pancreatic cancer.

Pancreatic cancer is one of the most aggressive cancers. Interleukin-22 (IL-22) is a member of IL-10 cytokine family and primarily produced by Th17 cells which were differentiated from CD4 T cells. CD4 T cells play a central role in regulating the immune response and resisting cancer cells.

Infiltrating CD4/CD8 high T cells shows good prognostic impact in pancreatic cancer.

Tumor infiltrating lymphocytes in a certain tumor microenvironment are associated with the prognosis of cancer patients. The function of CD4 and CD8 T cells in the microenvironment of pancreatic cancer remains largely unknown. This study aimed to investigate the prognostic value of both CD4 and CD8 TIL subsets and their combined role in pancreatic cancer.

Association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function.

Objectives: The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function.

Methods: Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrhosis and determine the Laennec staging system. The association of the Laennec staging system with the degree of cirrhosis, clinical stage and liver function was compared.

Effect of hepatic blood inflow occlusion without hemihepatic artery control on apoptosis of liver cells in rats.

Background/aims: To investigate the effect of hepatic blood inflow occlusion without hemihepatic artery control on the apoptosis of liver cells during ischemia-reperfusion injury in rats.

Methodology: Animal models of three hepatic vascular occlusion methods were established. Hepatic blood inflow occlusion without hemihepatic artery control (WH group), hemihepatic vascular occlusion (HH group) and Pringle maneuver (PR group) were compared.